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Returning to Nur's Ship, Nur demanded to know why the plague was not complete and Mr.

Sinister stated that he manipulated the plague, so that it would affect only Nur himself, but his immune system quickly adapted to it. Sinister replied that cruelty for no purpose was ignorance and ignorance was the greatest enemy of science.

Deciding to leave his life of unorthodox science and dedicate his life to his wife and unborn child, Dr. Essex took the new name, "Sinister", Rebecca's last words to him. Sinister stated that he willingly allowed whatever humanity he had to be carved out of him, all for the sake of science.

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Essex believed that the sanctity and purity of it was heaven on Earth. Essex later became a biologist in 1859 Victorian England. Essex was regarded, by some, to be the greatest scientific mind of his generation, and, by others, as a dangerous man twisted by the obsession of his own research. Essex believed in Darwin's theory of evolution and discovered that humanity was undergoing increasing mutation, due to what he called “Essex Factors” in the human genome. Essex also believed that, in the offspring of certain racially superior individuals, these parcels will, within a hundred years or so, mutate. Essex's theories were mocked, making him bitter, and his revealing of an unorthodox experiment resulted in his ousting from the Royal Society. Essex see a physician due to the trauma of losing his son. Essex stated to Darwin that if becoming a monster was what was required for science to progress, then he would become a monster. Essex was taken underground, where the Mauraders were collecting freaks, fools, and all types of misshapen folk off the streets of London. Essex hired the thugs to continue their work, so he could perform experiments on the victims in the name of science.Essex's lab, to find the body of their son in an incubation tube. Essex explained to Nur that he was the first born in, what Dr.After digging-up Adam's grave to prove her suspicions, Rebecca passed-out, from the shock of finding the coffin empty, and Nur approached Dr. Left with the choice of continuing his work or his wife shunning him, Dr. Essex believed, would be a great mutation in the human race.Unfortunately for Sinister Apocalypse's ability for his molecular structure to adapt is able to fight the virus and is only weakened by it.He threatens Sinister if they were to ever meet again, Apocalypse would kill him. This partially drove his desire to find and create a powerful mutant in order to defeat Apocalypse later on.